Medical Journals

An effective and accurate semi-implicit time integration scheme for dynamics in nearly- and fully-incompressible hyperelastic solids.

Authors: Edward M Terrell, Marshall Davey, David R Wells, Boyce E Griffith

The choice of numerical integrator in approximating solutions to dynamic partial differential equations depends on the smallest time scale of the problem at hand. Large-scale deformations in elastic solids contain both shear waves and bulk waves, the latter of which can travel infinitely fast in incompressible materials. Explicit schemes, which are favored...

Rapid and accessible tumor necrosis factor alpha detection using digital nanoparticle sensors towards point-of-care cytokine monitoring.

Authors: Maziyar Kalateh Mohammadi, Mohammad Altarfa, Seyedsina Mirjalili, Md Ashif Ikbal, Yeji Choi, Chao Wang

Cytokine monitoring is essential for understanding immune response and evaluating therapeutic outcomes in inflammatory and autoimmune diseases. Here, Tumor Necrosis Factor-alpha (TNF-α) is employed as an exemplary cytokine marker to demonstrate a nanoparticle-supported, rapid, electronic detection (NasRED) assay as an one-pot, in-solution sensing platform...

OpticalFlow3D - a tool for measuring amorphous motion in three-dimensional fluorescence microscopy images.

Authors: Rachel M Lee, Leanna R Eisenman, Chad M Hobson, Jesse S Aaron, Teng-Leong Chew

Motion is an essential component of any living system. It is rich with information, but it is often challenging to quantitatively extract biologically informative results from the motion apparent in microscopy images. This challenge is exacerbated by the wide variety in biological movement, which often takes the form of difficult-to-segment amorphous...

Electrothermally Addressable Liquid Crystal Elastomer Microactuator Arrays with Integrated Microheaters.

Authors: Ke Li, Jayer Fernandes, Jae-Jun Kim, Hongrui Jiang

Liquid crystal elastomers (LCEs) are attractive for microscale actuation because they exhibit large, reversible, and programmable deformation. However, practical LCE microsystems remain difficult to realize due to challenges in fabricating discrete actuator arrays and achieving localized, electrically addressable actuation. Existing localized driving...

Sexual health literacy as a predictor of reproductive health and family planning attitudes among university students: a cross-sectional study.

Authors: Aysu Yıldız Karaahmet, Fatma Şule Bilgiç, Sevda Karakaş

INTRODUCTION: This study was conducted to investigate the relationship between sexual health literacy (SHL) and reproductive health and family planning (RHFP) attitudes among university students and to identify the sociodemographic and informational predictors influencing these variables. METHODS: A descriptive, cross-sectional design was employed with a...

Profiles of distress related to sexual function, psychological distress, and sexual pleasure: a person-centered analysis of early maladaptive schemas and psychological inflexibility.

Authors: Valentim P Santos, Pedro J Rosa, Magda S Roberto, Andreia A Manão, Cátia Oliveira, Nuno Tomada, Joachim Osur, Diogo Telles-Correia, Patrícia M Pascoal

BACKGROUND: Sexual distress and sexual pleasure are two clinically distinct parameters used to evaluate sexual dysfunction, alongside psychological distress. Various psychological processes and problems have been implicated in the etiology and maintenance of sexual dysfunction. Two transdiagnostic processes, Early Maladaptive Schemas (EMS) and...

The onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation.

Authors: Omar Flores-Sandoval, Skarleth Cárdenas-Romero, Adrián Báez-Ruiz, Roberto C Salgado-Delgado, Nadia Saderi

Increased sympathetic tone and hypertension are hallmarks of metabolic syndrome and contribute to chronic kidney disease. Although renal sympathetic denervation transiently lowers blood pressure, its role in the development of metabolic and renal alterations remains unclear. Here, we evaluated the contribution of renal sympathetic input to the onset and...

SATB1 preserves CD4+ T-cell fidelity and establishes Treg function in antitumor immunity.

Authors: Wooseok Seo, Chengcheng Zou, Kanako Shimizu, Ruka Setoguchi, Kiyokazu Kakugawa, Terumi Kohwi-Shigematsu, Shohei Hori, Shin-Ichiro Fujii, Hiroyoshi Nishikawa, Ichiro Taniuchi

The genome organizer special AT-rich sequence binding protein 1 (SATB1) is critical for the development of T lymphocyte subsets by regulating Foxp3 and Pdcd1 expression. However, its physiological role in mature peripheral T cells has remained obscured by the severe developmental defects caused by early-stage gene knockout models. Here, we used a Thpok-cre...

Spatio-Temporal Sensitivity of Healthcare Accessibility: Insights from a System Dynamics Model.

Authors: Patrick Danso, Liang Mao

Recent research has increasingly focused on modeling the spatiotemporal dynamics of healthcare accessibility. However, a critical gap remains in understanding the relative influence of underlying factors, such as travel propensity, service availability, and population demand, and particularly how their influence varies across space and time. To address...

Iliac artery endofibrosis treated by endarterectomy with patch angioplasty via a retroperitoneal approach in an amateur triathlete.

Authors: Kohei Ueno, Koichi Morisaki, Go Kinoshita, Shinichiro Yoshino, Kentaro Inoue, Tomoharu Yoshizumi

Iliac artery endofibrosis is a nonatheromatous vascular disease observed in endurance athletes. A 46-year-old female amateur triathlete presented with exercise-induced claudication of the left leg. The resting ankle-brachial index was normal, but the postexercise ankle-brachial index decreased on the left side. Computed tomography angiography showed...

Identification and endovascular treatment of a rare deep circumflex iliac artery-L3 lumbar artery anastomosis causing type II aortic aneurysm endoleak.

Authors: Jacob Fryer, Michael Shonnard, Ronald Blasini, James Mega

Type II endoleaks are the most common complication after endovascular aneurysm repair typically arising from mesenteric and lumbar inflow vessels, whereas alternative collateral sources are less frequently recognized. We report a case of a deep circumflex iliac artery-mediated collateral causing persistent sac perfusion, identified on preprocedural imaging...

Mapping Meiotic Recombination DNA Double-Strand Breaks (DSBs) Hotspots -Methodological Advances and Challenges.

Authors: Jianqiang Bao

Programmed DNA double-strand breaks (DSBs) initiate meiotic recombination at discrete genomic hotspots, and their precise mapping is crucial for understanding the molecular regulation of genome stability and evolution. A variety of genome-wide methods have been developed, each leveraging different biochemical principles - from direct capture of...

Prediction of arrhythmogenesis in non-ischemic cardiac resynchronization therapy patients.

Authors: Alessandra Corda, Massimiliano Maines, Stefano Pagani, Domenico Catanzariti, Maurizio Del Greco, Christian Vergara

We aim to develop a patient-specific computational model to predict the risk of Ventricular Tachycardia (VT) in patients with a Biventricular Cardiac Resynchronization Therapy (BiV-CRT) device. Patients are indeed at risk of developing arrhythmias due to BiV-CRT pacing, a known potential complication that requires preventive evaluation. We consider three...

Clinical differentiation between pediatric pulmonary tuberculosis and Mycoplasma pneumoniae pneumonia (Review).

Authors: Zong Wan, Renjie Qi, Qiushi Yang, Huan Li, Shusong Ruan

Differentiating between pediatric pulmonary tuberculosis (TB) and Mycoplasma pneumoniae pneumonia (MPP) is essential due to their overlapping clinical manifestations yet distinct therapeutic approaches. TB is characterized by a chronic progression, accompanied by constitutional symptoms and specific radiological features such as lymphadenopathy and...

[Retracted] Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.

Authors: Ming-Ming Cao, Xi Lu, Guo-Dong Liu, Ying Su, Yan-Bo Li, Jin Zhou

[This retracts the article DOI: 10.3892/etm.2017.5400.].

Variability in the management of healthy short youth following GH stimulation testing.

Authors: Adda Grimberg, Victoria A Miller, Morgan P Snyder, Elizabeth A Friedrich

BACKGROUND/OBJECTIVES: Recent Delphi survey of endocrinologists revealed low consensus regarding the diagnosis of pediatric growth hormone deficiency (GHD). Thus, we sought to describe the various trajectories undertaken by healthy 8-14 year old youth in the 2 years following testing for GHD at a single major pediatric academic institution. METHODS:...

Bimetallic nanozymes with galvanic cell effects eradicate intratumoral bacteria and tumor cells to overcome drug resistance and potentiate antitumor immune responses for tumor therapy.

Authors: Jianlin Wang, Zhenning Su, Xin Zhang, Siyu Wang, Xihua Chen, Xiangbo Xu, Bin He, Yufeng Zheng

Intratumoral bacteria have attracted considerable attention as critical components of the tumor microenvironment (TME) that influence tumor initiation, progression, therapeutic efficacy, and immune responses. Conventional antibiotic approaches for eradicating intratumoral bacteria are limited by severe side effects, disruption of microbial homeostasis, and...

ProteoMeter: a pipeline for integrating multi-PTM and limited proteolysis data to reveal modification-structure coupling at the residue level.

Authors: Jordan C Rozum, Amy C Sims, Xiaolu Li, Snigdha Sarkar, Tong Zhang, John T Melchior, Danielle Ciesielski, David D Pollock, H Steven Wiley, Wei-Jun Qian, Song Feng

Systemic perturbations trigger extensive changes across the proteome-altering protein abundance, post-translational modifications (PTMs), conformational states, and complex assembly. Interpreting these effects demands computational pipelines capable of integrating diverse proteomics modalities, such as multi-PTM profiling, limited proteolysis mass...

Sarand: exploring antimicrobial resistance gene neighbourhoods in complex metagenomic assembly graphs.

Authors: Somayeh Kafaie, Shahlla Naseri, David B J Mahoney, Travis Gagie, Robert G Beiko, Finlay Maguire

Antimicrobial resistance (AMR) is a major global challenge to human and animal health. The genomic element (e.g. chromosome, plasmid, and genomic islands) and neighbouring genes associated with an AMR gene play a major role in its function, regulation, evolution, and propensity to undergo lateral gene transfer. Therefore, characterizing these genomic...

Right Ventricular Function Improves With Pulmonary Vasodilator Treatment in Pediatric Patients With Pulmonary Hypertension and Multivessel Pulmonary Vein Stenosis in a Single Center Cohort.

Authors: Catherine M Avitabile, Kimberly Butler, Antara Mondal, David B Frank, Yan Wang, Devon Ash, Laura Mercer-Rosa, Michael L O'Byrne, Ryan Callahan

Pulmonary hypertension (PH) and right ventricular (RV) dysfunction increase mortality in multivessel pediatric pulmonary vein stenosis (PVS). Pulmonary vasodilator use is limited in PVS due to the perceived risk of pulmonary edema. We aimed to describe our experience with pulmonary vasodilators in PVS and to assess changes in RV function and hemodynamics...

Smoking-Related Clinical and Molecular Abnormalities in Idiopathic Pulmonary Fibrosis-Associated Pulmonary Hypertension.

Authors: Iryna Zhyvylo, Namita Sood, Janelle Vu Pugashetti, Angela L Linderholm, Ssu-Wei Hsu, Justin Oldham, Ching-Hsien Chen, Elena A Goncharova

Pulmonary hypertension (PH) is a frequent complication of interstitial lung diseases (ILD) that worsens morbidity and mortality. Cigarette smoking has a detrimental effect on transplant-free survival of patients with ILD, including patients with idiopathic pulmonary fibrosis (IPF). However, smoking-related molecular alterations in patients with ILD-PH are...

Minimally Invasive Porcine Model for Chronic Thromboembolic Pulmonary Hypertension.

Authors: Bianca Battilana, Christian T Stoeck, Fabien Robert, Ömer Senbaklavaci, Miriam Weisskopf, Isabelle Opitz

To elucidate the complex pathophysiology of chronic thromboembolic pulmonary hypertension (CTEPH), a disease associated with bilateral fibrotic obstructions of the pulmonary arteries (PA) and microvascular changes, research relies on animal models, which often depend on invasive techniques, including open surgery. As animal welfare is a major priority for...

Immune Cell Responses to Fluid Shear: Overview and Design Considerations for In Vitro Modeling.

Authors: Eric L Ginter, Laurel E Hind

Fluid flow is ubiquitous throughout the immune system. Immune cells exhibit sensitivity to fluid shear stress, altering their activation and behavior in response to the presence, magnitude, and timing of fluid flow. Therefore, understanding how flow regulates the immune response is crucial for understanding the immune system's contribution to homeostasis,...

Orexin, Sleep, and Cognition in Alzheimer Disease: Non-REM Oscillatory Activity and Neural Resilience.

Authors: Arsenio Paez, Gerard Piñol-Ripoll, Anna Carnes-Vendrell, Farida Dakterzada, Ferran Barbé, Henrik Zetterberg, Thien Thanh Dang-Vu

BACKGROUND AND OBJECTIVES: Sleep-wake dysregulation and elevated CSF orexin have been implicated in Alzheimer disease (AD). Sleep spindles (SPs) and slow oscillations (SOs) are linked to cognition and neurodegeneration; however, their relationship with CSF orexin concentrations in symptomatic AD has not been characterized. We investigated whether nonrapid...

Legal Protections to Mitigate Discrimination due to Neurodegenerative Biomarker Status.

Authors: Jalayne Arias, Drew Blasco, Anya E R Prince, Emily A Largent

It is a critical time to advance solutions that would mitigate the perceived, potential, and actual risk of discrimination based on neurodegenerative biomarker information. Across neurodegenerative conditions, biomarkers are being evaluated to detect disease pathology before the onset of clinically measurable symptoms. Clinical adoption and research that...

Two-Year Retention of Benefits After Paired Vagus Nerve Stimulation in Stroke: Follow-Up of the VNS-REHAB Randomized Clinical Trial.

Authors: Teresa J Kimberley, Isha Vora, Steven C Cramer, Steven L Wolf, Jesse Dawson, VNS-REHAB Trial Group

OBJECTIVES: Vagus nerve stimulation (VNS) paired with rehabilitation improves short-term upper extremity (UE) function in people with chronic ischemic stroke. Because sustained improvements are needed for people with stroke, we examined the long-term effects of Paired VNS on impairment, activity, participation, and quality of life. METHODS: This is a post...

Prenatal Brain MRI Manifestations of TSC2/PKD1 Contiguous Gene Deletion Syndrome in a Fetus.

Authors: Linjun Xie, Yingkun Guo, Xiaoxue Yi, Rong Xu

Controlling scissors during DNA repair of UV light-induced damage.

Authors: Patricia L Opresko, Orlando D Schärer

Nucleotide excision repair is essential for genome stability; however, enzymatic scissors that remove damage must be tightly regulated to prevent erroneous DNA cleavage. In this issue, Muniesa-Vargas et al. (https://doi.org/10.1083/jcb.202602121) used live-cell imaging to uncover how cutting DNA by XPG endonuclease is controlled during repair.

Revision total elbow arthroplasty for aseptic and septic nonunion of distal humerus fractures: a case series.

Authors: Alyssa A Federico, Adina Tarcea, Sara Kayvani, Kevin A Hildebrand, Neil J White

BACKGROUND: Distal humerus fractures can be difficult to manage in older patients with poor bone quality and those with risk factors for failure of open reduction internal fixation. When nonunion occurs, there are limited repeat fixation options and conversion to total elbow arthroplasty (TEA) can be considered. The objective of this descriptive,...

Advancing surgical techniques with ligasure for common femoral artery exposure.

Authors: Michael J Singh

Postoperative outcomes of ligasure use during common femoral artery exposure.

Authors: Koyal Ansingkar, Brittany Landavazo, Brianna Elys Whithorn, Maham Rahimi

OBJECTIVE: Seroma formation after common femoral artery (CFA) exposure is a recognized complication in vascular surgery, associated with delayed wound healing and graft-related morbidity. Reported seroma rates following CFA exposure using standard electrocautery range from 5% to 15% for cases requiring operative reintervention. The LigaSure bipolar vessel...

Drilling a safer path: Reconsidering the iliac wing as a reconstructive corridor.

Authors: Apoorva Bhandari, Matthew R Smeds

Identifying diabetic ketoacidosis encounters at diagnosis among children with type 1 diabetes in claims data.

Authors: R Brett McQueen, Nai-Chia Chen, Eric J Gutierrez, Kelly E Anderson, G Todd Alonso

BACKGROUND: Quantify the performance of claims data in identifying diabetic ketoacidosis (DKA) cases and estimate healthcare resource utilization among newly diagnosed type 1 diabetes patients with and without DKA. METHODS: We matched individuals RESULTS: After applying algorithms for identifying type 1 diabetes with continuous enrollment criteria, n = 728...

Percent body fat misclassifies patients with sarcopenia as obese: support for fat mass index in obesity assessment.

Authors: Susan L Ziolkowski, David R Weber, Joshua F Baker

BACKGROUND: Percent body fat (%BF) is a common measurement reported on dual-energy X-ray absorptiometry (DXA) to assess for obesity. %BF is calculated as fat mass divided by total body mass, and thereby increases with either higher fat mass or reduced muscle mass. In contrast, fat mass index (FMI; kg/m2) quantifies fat mass independent of muscle mass. It...

Major Cardiovascular Complications of Index Kidney Transplantation Hospitalizations: A National Inpatient Sample Analysis.

Authors: Spencer R Goble, Thomas M Leventhal, Justin R Parekh

BACKGROUND: Understanding perioperative risks and long-term benefits of kidney transplantation is essential for patient counseling and optimization of posttransplant outcomes. Currently, there is a lack of generalizable data on cardiovascular complications of kidney transplantation. METHODS: We performed a retrospective, cross-sectional analysis of adult...

Book Essay: Profile: Salman AkhtarSelected Papers of Salman Akhtar (Volumes I-X). By Salman Akhtar. Bicester, UK: Phoenix, 2023, 4,272 pp., $1,100 hardcover.Tales of Transformation: A Life in Psychotherapy and Psychoanalysis. By Salman Akhtar. Bicester, UK: Phoenix, 2021, 248 pp., $45 paperback.

Authors: Indrany Datta-Barua

Book Essay: How the Light Gets BlockedThe Digital and Its Discontents. By Aden Evens. Minneapolis: University of Minnesota Press, 2024, 264 pp., $29.00 paperback.Psychoanalysis and Narrative: Literature, Film and Autobiography. By Jorgelina Corbatta. New York: Routledge, 2025, 212 pp., $45.59 paperback.

Authors: J Todd Dean